What are the Others? What is the source of their power/ Do they affect the length of WInter?
Are Jaqan and Syrio the same person? Is Syrio dead (if they aren't)?
Will Jorah Mormont try to harm/kill Dany as a way of seeking revenge?
Will Jon Snow become King of Winterfell?
Will it be Sansa that ultimately kills Littlefinger?
Is Varys a Faceless Man?
Will the "Song of Ice and FIre? be a showdown between the Others and the united forces of Westeros or between The Starks and Targs?
WHat will the new POV be?
How long will Arya remain blind for?
How will Cersei be "extricated" from her current predicament?
Which "side" will Jaime end up on? (I'm not convinced he will remain loyal to what's left of his family)
Will all the Starks with wolves be able to shapeshift?
Was the large, ornatge Horn of Winter that Jon saw in the possession of Manse Rayder the true Horn or was it really the small plain one he found buried along with the obsidian shards and cloak?
Is Benjin dead?
Who/what is the Three Eyed Crow?
Will Melisandre be able to "hatch" a dragon, and if so, whose blood will be used? Jon Snow's. The Manse's child?
What will be the "real betrayals" )re; Dany)
Who is Coldhands?
How will the "Frankenstien" Gregor come into play?
Will Oleanna Martell's role in the conspiracy to kill Joffrey ever become known?
What will Howland Reed's role be? Will we meet him in ADWD? Will he reveal what happened in the TOJ?
I'll probably think of others the second I hit post