A few major ones are, like dead people turning up at weddings. Is this on PC or console? Im in two minds about it, and my main suggestion would be "yes, but make sure you go somewhere with internet access once in a while to get the updates"
BTW the PC one runs on Steam so needs the internet for Steam access, during install anyway - at least I guess it does (I have internet and Steam already installed, so not sure what the installation does if you don't have internet and Steam....)