You might want to checkout the science fiction novel The Gladiator by Phillip Wylie Its something of a precursor to Superman
In that case, the story is more cautionary. He is given freakish powers due to scientific experiment--it's more along the lines of "not meddling in things beyond your grasp."
Superman only had powers because of the alien sun.
There was a German film with a similar idea--it sounds like if the author had wanted to expand the story, this would have been the direction it could have gone:
"'Homunculus' was the most popular serial in Germany during World War I even influencing the dress of the fashionable set in Berlin. Foenss, a Danish star, is the perfect creature manufactured in a laboratory by Kuehne. Having discovered his origins, that he has no 'soul' and is incapable of love, he revenges himself on mankind, instigating revolutions and becoming a monstrous but beautiful tyrant, relentlessly pursued by his creator-father who seeks to rectify his mistake."
Consider Captain Marvel--he was a child-also an orphan, who is given powers because he is recognized as having some noble or merit qualities. That's kind of a variation on the Ugly Duckling, but his powers come from the Earth--they come from Earth myth figures, not aliens. He is a more "homey" kind of superhero than Superman.
Another thing is that in some ways Lex Luthor and Batman are similar--they are both industrialist geniuses. Batman's antagonism to Superman also grew in time-less trusting of him compared to the original team up stories.
Another thematic issue is Nature vs Nurture.
Back to the Future is a good example--that's Nurture over Nature. The idea is that a single event can alter one's personality and behavior.
George McFly completely changes in personality.
But you don't find that in Poe--in this stories there's the creep of hereditary madness--Nature over Nurture.
Speaking of Matheson again-his story for the Pit and the Pendulum--it combines Poe elements but also subverts them.
Nicholas is traumatized by the memory of his sadistic father killing his adulterous mother---and his wife schemes to drive him mad for her own purposes but it causes him to mentally snap and think he is his own father. Is it Nature over Nurture? or Nurture over Nature. It is debatable.
I love this topic.