I don't think efforts to get to Mars, and especially the Moon, are that far away. Space flight is a big part of science fiction that seems like it must true. It could be similar to crossing the Atlantic 700 years ago, and you can pretty much see what's there before you get there now. Workers health has never been a big priority and if the work has a high status value, everyone is willing to let people do what they want to do.
100 years ago airplanes were a very big deal, carried a lot of risk, and every other day a plane fell out of the sky. A lot of people didn't know what aviation could be good for or how it would change the world, but that didn't stop anyone. People like Musk have no sense of reality as they simply buy solutions to any problems they may come across. If he wants to go to Mars, then he will do whatever he has to to get people there. The other day he said his company (shades of Alien!) could be on Mars in 3 or 4 years. I think part of the drive is fueled by the idea that there might be something on the Moon or Mars that will prove to have great technological value back on Earth that will be incredibly useful and of course extremely valuable. In layman's terms it's called gold fever, but if his space ships work, I think it's a done deal.
In 7 years, the space station is supposed to be demolished by a space tug boat that will push it into a planned descent where it burns up over a vast expanse of ocean. The tub boat is an engine attached to a big fuel tank. If it can be built and successfully launched, that design could go a long way towards powering space flight. The "big" ships wouldn't have to return to Earth every time, they could get refueled in space. That takes a lot of wear and tear out of the equation. The ships stay in space, and the crews and supplies go back and forth between Earth and the ship.
For a while everything would be neutral, happy days, but eventually there might be some temptation to arm the ships with weapons that are far in excess of what is needed, like in case of space pirates, which could provide an even bigger reason for having a presence in space.