Not so much looking at the long-term risks that the ship might encounter, like being attacked by unfriendly aliens or similar, but what kind of setup do you want the ship to have?
Something like Star Trek TNG where the Enterprise D is a multirole ship, plenty of state-of-the-art sensors and science labs as well as excellent diplomacy facilities, and family-friendly setups as the scientists and other crew are able to bring their families on board for the long-term voyage.
Something more like Red Dwarf where the ship has a specific main function, mining, but also carries cargo and has minimal scientific or exploration roles, no signs of families but plenty of entertainment facilities like nightclubs, cinemas and so on.
Something else altogether? After all, the universe if your oyster.
Something like Star Trek TNG where the Enterprise D is a multirole ship, plenty of state-of-the-art sensors and science labs as well as excellent diplomacy facilities, and family-friendly setups as the scientists and other crew are able to bring their families on board for the long-term voyage.
Something more like Red Dwarf where the ship has a specific main function, mining, but also carries cargo and has minimal scientific or exploration roles, no signs of families but plenty of entertainment facilities like nightclubs, cinemas and so on.
Something else altogether? After all, the universe if your oyster.