The movie's certainly amazing for its time, although sometimes I wonder what substance Kubrick was on when he invented the ending sequence. That's enough to give epileptics a photosensitive seizure.
Looking back, the thing that jars me most is the 1960s conception of "futuristic" furniture. Looks like leftovers from the early 1970s...
There's quite amazing cinematography in the movie. I especially remember the centrifuge running sequence and the discussion between the two crewmen in the spacepod, with HAL's malevolent red eye looking at them through the porthole.
The book is a good read too, and apparently they were written more or less in tandem, with some modifications made even after scenes were shot. A rather expensive way of writing a novel if you ask me!
There are also some significant differences, in the movie and in the sequels, the events happen in the orbit of Jupiter, with Io being the moon where the Stargate is located. In 2001, Discovery uses the slingshot effect off Jupiter to get to Saturn, and there the moon of choice is the two-faced Iapetus (Japetus), so named after the Roman (or ancient Greek?) god with two faces. On Iapetus, one face is much darker than the other, hence the name.