Convergent evolution is what I'm going to hang my hat on, seeing all the coats have been taken.
Eyes have developed as eyes a number of times, so evolution likes eyes of a certain model. They may look different, but in general eyes are usually in eye balls, with a hole to let light in on one side. You get the idea.
Anyway... when dreaming up your alien try and keep them functional. The Blob (I loved the movie, but didn't really believe the idea) being a jelly mass on land may have worked for Hollywood, but I'd expect better of the members on this forum. Functional however takes many forms and we've had birds in New Zealand fill a lot evolution gaps on that island, so there is a massive scope for being creative. However, I think most advanced aliens will have evolved from hunters, as hunters have to use the grey mass to stalk pray and will be a more clever animal (a rule, but not a golden rule I'd say). I also think there has to be some spare limbs (our arms) to use tools and weapons to advance our aliens from the stone age onwards. This is why we walk on two feet, as we had found another use for our arms (carrying infants across grasslands to start with, but later spears and other weapons). Naturally of course, fairly large so they can support a large brain. So apply a logic to your alien and think about how they may have developed. The rest is up to you.
By the way, I have large Birds, a Kangaroo/Dog mix and my Many (on four legs, with trunk like arms and about the size of a pig) as the first of my aliens. Only two of the three are bipedal here, so go play and have fun.