If I bolded the ones I've read...there would be embarrassingly few. Instead, I wondered how many of these are on the wonderful top 200 from
Sci-Fi Lists, which is my go to site when I want to read a new sci-fi or fantasy book. It has the added advantage of ranking books from best to not-as-best, instead of chronologically.
So, in bold are the books that appear on the Sci-Fi Lists list, which is:
"A statistical survey of sci-fi literary awards, noted critics and popular polls. To qualify a book has to be generally regarded as science fiction by credible sources and/or recognised as having historical significance to the development of the genre."
1818 FRANKENSTEIN MARY SHELLY
1864 JOURNEY TO THE CENTRE OF THE EARTH JULES VERNE
1870 TWENTY THOUSAND LEAGUES UNDER THE SEA JULES VERNE
1895 THE TIME MACHINE H.G. WELLS
1896 THE ISLAND OF DR. MOREAU H.G. WELLS
1898 WAR OF THE WORLDS H.G. WELLS
1912 THE LOST WORLD SIR ARTHUR CONAN DOYLE
1917 A PRINCESS OF MARS EDGAR RICEBURROUGHS
1930 LAST AND FIRST MEN OLAF STAPLEDON
1932 BRAVE NEW WORLD ALDOUS HUXLEY
1933 THE SHAPE OF THINGS TO COME H.G. WELLS
1937 STAR MAKER OLAF STAPLEDON
1938 OUT OF THE SILENT PLANET C.S. LEWIS
1940 SLAN A.E. VAN VOGT
1945 THE WORLD OF NULL-A A.E. VAN VOGT
1947 GREENER THAN YOU THINK WARD MOORE
1948 TRIPLANETARY E.E. ‘DOC’ SMITH
1949 NINETEEN EIGHTY-FOUR GEORGE ORWELL
1949 EARTH ABIDES GEORGE R. STEWART
1950 I, ROBOT ISAAC ASIMOV
1950 GATHER DARKNESS FRITZ LEIBER
1951 THE MARTIAN CHRONICLES RAY BRADBURY
1951 THE DAY OF THE TRIFFIDS JOHN WYNDHAM
1951 FOUNDATION ISAAC ASIMOV
1952 CITY CLIFFORD D. SIMAK
1952 THE ILLUSTRATED MAN RAY BRADBURY
1953 CHILDHOOD’S END ARTHUR C. CLARKE
1953 THE DEMOLISHED MAN ALFRED BESTER
1953 MORE THAN HUMAN THEODORE STURGEON
1953 THE KRAKEN WAKES JOHN WYNDHAM
1953 THE SPACE MERCHANTS CM KORNBLUTH & FREDERICK POHL
1953 FARENHEIT 451 RAY BRADBURY
1954 BRAIN WAVE POUL ANDERSON
1954 A MISSION OF GRAVITY HAL CLEMENT
1954 WILD TALENT WILSON TUCKER
1954 I AM LEGEND RICHARD MATHESON
1955 THE CHRYSALIDS JOHN WYNDHAM
1956 TIGER! TIGER! ALFRED BESTER (a.k.a.The Stars My Destination)1956 THE DOOR INTO SUMMER ROBERT A.HEINLEIN
1957 BIG PLANET JACK VANCE
1957 EARTH IS ROOM ENOUGH ISAAC ASIMOV (short stories)
1957 THEY SHALL HAVE STARS JAMES BLISH
1957 WASP ERIC FRANK RUSSELL
1957 THE MIDWICH CUCKOOS JOHN WYNDHAM
1958 THE BIG TIME FRITZ LEIBER
1958 STARBURST ALFRED BESTER (short stories)
1959 STARSHIP TROOPERS ROBERT A. HEINLEIN
1959 A CANTICLE FOR LIEBOWITZ WALTER M. MILLER Jnr.
1959 THE SIRENS OF TITAN KURT VONNEGUT
1960 DORSAI! GORDON R. DICKSON
1960 ROGUE MOON ALGYS BUDRYS
1961 STRANGER IN A STRANGE LAND ROBERT A. HEINLEIN
1961 SOLARIS STANISLAW LEM
1962 A CLOCKWORK ORANGE ANTHONY BURGESS
1962 THE DROWNED WORLD J.G. BALLARD
1962 THE SWORD OF ALDONES MARION ZIMMER BRADLEY
1963 WAY STATION CLIFFORD D. SIMAK
1964 GREYBEARD BRIAN ALDISS
1965 DUNE FRANK HERBERT
1966 THIS IMMORTAL ROGER ZELAZNY
1966 FLOWERS FOR ALGERNON DANIEL KEYES
1966 MAKE ROOM! MAKE ROOM! HARRY HARRISON
1967 THE EINSTEIN INTERSECTION SAMUEL R. DELANEY
1967 LORD OF LIGHT ROGER ZELAZNY
1968 DO ANDROIDS DREAM OF ELECTRIC SHEEP?
1968 PAVANE KEITH ROBERTS
1968 RITE OF PASSAGE ALEXEI PANSHIN
1968 THE SANTAROGA BARRIER FRANK HERBERT
1968 STAND ON ZANZIBAR JOHN BRUNNER
1968 DRAGONFLIGHT ANNEMcCAFFREY
1969 THE LEFTHAND OF DARKNESS URSULA K. LE GUIN
1969 BUG JACK BARRON NORMAN SPINRAD
1969 SLAUGHTERHOUSE-FIVE KURT VONNEGUT
1969 NIGHTWINGS ROBERT SILVERBERG
1969 THE SILKIE A.E. VAN VOGT
1970 RINGWORLD LARRY NIVEN
1970 TAU ZERO POUL ANDERSON
1972 THE FIFTH HEAD OF CERBERUS GENE WOLFE
1972 DYING INSIDE ROBERT SILVERBERG
1973 RENDEZVOUS WITH RAMA ARTHUR C. CLARKE
1974 THE MOTE IN GOD’S EYE LARRY NIVEN & JERRY POURNELLE
1974 THE DISPOSSESSED URSULA K. LE GUINN
1974 A KNIGHT OF GHOSTS AND SHADOWS POULANDERSON
1975 THE FOREVER WAR JOE HALDEMAN
1975 ORBITSVILLE BOB SHAW
1975 MIDWORLD ALAN DEAN FOSTER
1976 MAN PLUS FREDERICK POHL
1976 DOORWAYS IN THE SAND ROGER ZELAZNY
1977 MICHAELMAS ALGIS BUDRYS
1977 ROADSIDE PICNIC ARKADY AND BORIS STRUGATSKY
1977 THE OPHIUCHI HOTLINE JOHN VARLEY
1977 GATEWAY FREDERICK POHL
1977 A SCANNER DARKLY PHILIP K. DICK
1978 DREAMSNAKE VONDA N. McINTYRE
1979 THE FOUNTAINS OF PARADISE ARTHUR C. CLARKE
1980 TIMESCAPE GREGORY BENFORD
1980 WILD SEED OCTAVIA BUTLER
1981 DOWNBELOW STATION C.J. CHERRYH
1982 HELLICONIA SPRING BRIAN ALDISS
1982 THE PRIDE OF CHANUR C.J. CHERRYH
1983 THE VOID CAPTAIN’S TALE NORMAN SPINRAD
1983 STARTIDE RISING DAVID BRIN
1984 NEUROMANCER WILLIAM GIBSON
1985 ENDER’S GAME ORSON SCOTT CARD
1986 SHARDS OF HONOUR LOIS McMASTER BUJOLD
1986 SPEAKER FOR THE DEAD ORSON SCOTT CARD
1988 THE EMPIRE OF FEAR BRIAN STABLEFORD
1988 WHORES OF BABYLON IAN WATSON
1988 GREAT SKY RIVER GREGORY BENFORD
1988 IVORY MIKE RESNICK
1988 ARAMINTA STATION JACK VANCE
1988 CYTEEN C.J. CHERRYH
1988 PLAYER OF GAMES IAIN M. BANKS
1989 HYPERION DAN SIMMONS
1989 PARADISE MIKE RESNICK
1990 THE FALL OF HYPERION DAN SIMMONS
1990 EARTH DAVID BRIN
1991 JURASSIC PARK MICHAEL CRICHTON
1992 DOOMSDAY BOOK CONNIE WILLIS
1992 A FIRE UPON THE DEEP VERNOR VINGE
1992 RED MARS KIM STANLEY ROBINSON
1992 SNOW CRASH NEAL STEPHENSON
1992 QUARANTINE GREG EGAN
1994 VURT JEFF NOON
1994 FOREIGNER C.J. CHERRYH
1994 MIRROR DANCE LOIS McMASTER BUJOLD
1995 FAIRYLAND PAUL J. McCAULEY
1995 THE TERMINAL EXPERIMENT ROBERT J. SAWYER
1996 SPARES MICHAEL MARSHALL SMITH
1996 THE DIAMOND AGE NEAL STEPHENSON
1996 HONOR AMONG ENEMIES DAVID WEBER
1997 FRAME SHIFT ROBERT J. SAWYER
1998 THE SPARROW MARY DORIA RUSSELL
1999 DREAMING IN SMOKE TRICIA SULLIVAN
1999 DARWIN’S RADIO GREG BEAR
1999 TIME STEPHEN BAXTER
1999 A DEEPNESS IN THE SKY VERNOR VINGE
2000 PEGASUS IN SPACE ANNE McCAFFREY
2000 REVELATION SPACE ALASTAIR REYNOLDS
2002 ALTERED CARBON RICHARD MORGAN
2002 SPEED OF DARK ELIZABETH MOON
2003 MAUL TRICIA SULLIVAN
2004 CLOUD ATLAS DAVID MITCHELL
2004 RIVER OF GODS IAN McDONALD
Out of the 144, the overlap is 80, just 56%.
Notable omissions include:
Hitchhiker's Guide to the Galaxy by Douglas Adams
2001: A Space Odyssey by Arthur C Clarke
The Moon is a Harsh Mistress by Robert A Heinlein
The Man in the High Castle by Philip K Dick
The Caves of Steel by Isaac Asimov
The Andromeda Strain by Michael Chrichton
A Wrinkle in Time by Madeleine L'Engle
Cat's Cradle by Kurt Vonnegut
Contact by Carl Sagan
The Gods Themselves by Isaac Asimov
Ubik by Philip K Dick
Time Enough for Love by Robert A Heinlein
Cryptonomicon by Neal Stephenson
The End of Eternity by Isaac Asimov
Battlefield Earth by L Ron Hubbard
The Reality Dysfunction by Peter F Hamilton
Ender's Shadow by Orson Scott Card
Eon by Greg Bear
To Your Scattered Bodies Go by Philip Jose Farmer
Lucifer's Hammer by Niven & Pournelle
The Handmaid's Tale by Margaret Atwood
The City and the Stars by Arthur C Clarke
Sphere by Michael Crichton
The Stainless Steel Rat by Harry Harrison
The Invisible Man by H G Wells
Citizen of the Galaxy by Robert A Heinlein
The Puppet Masters by Robert A Heinlein
Ilium by Dan Simmons
Have Space-Suit - Will Travel by Robert A Heinlein
Flatland by Edwin A Abbott
The Road by Cormac McCarthy
Old Man's War by John Scalzi
The Three Stigmata of Palmer Eldritch by Philip K Dick
Use of Weapons by Iain M Banks
The Lathe of Heaven by Ursula K Le Guin
The Cyberiad by Stanislaw Lem
VALIS by Philip K Dick
The Postman by David Brin
Strange Case of Dr Jekyll & Mr Hyde by Robert Louis Stevenson
The Many Colored-Land by Julian May
The Forge of God by Greg Bear
I Am Legend by Richard Matheson
Cities in Flight by James Blish
That's 43 from the top 100. They have online polls for sci-fi novels, short stories, TV shows and movies (and a fantasy site that does the same).