The closest thing I can think of is the film Star Wars, which didn't invent much, but copied from a lot of sources, gave a clear form to a lot of slightly vague ideas and - most of all - had a huge market. Of course, Star Wars is only one part of SF, and to some people it isn't science fiction at all, but to the great majority of people who aren't SF enthusiasts, their image of science fiction probably starts with "stuff like Star Wars".
Star Wars is a johnny-come-lately. People used to call it "that
Buck Rogers stuff".
But, yeah,
Star Wars has probably been the last thing to stamp a critical mass of the masses with an idea of "SF".
Pretty much dis-proven by 1920s. It's a fantasy, so often in SF presented as either something humans evolve to have in the future or that aliens have.
Not exactly. John W. Campbell got a BS in physics from Duke in 1932 and Rhine began doing experiments in parapsychology at Duke's
parapsychology lab in 1930 and continued on into the 60s (a major era for
Analog-ish psi power pstories). Now, I don't know if Rhine was faking or mistaken but he at least appeared to be using the scientific method in serious research and could easily have made quite an impression on Campbell and, while it was always fringe/minority, that would have appealed to Campbell's contrarian streak even more. (
Analog even today has an "Alternate View" column.) People tend to dismiss Campbell's ESP as pure silliness and it would be in writers today but people used to take phrenology and Freudianism seriously, too. Doing an ESP story in the 30s-60s is probably less silly than doing a Freud story and there were plenty of each.
(Plus telepathy beats the heck out of learning alien languages over long, boring periods of time.)
As far as the topic, while
Weird Tales existed and had its impact and both SF and fantasy conceptually predate their commercial genres, SF really became a thing with
Amazing and
Astounding - and
Amazing was originally built out of Poe, Verne, and Wells reprints and then gathered a host of writers and so on. It was always pretty communal and slow to develop and what developed was a huge variety of worlds and universes with and without spaceships and aliens and robots and covered the past, present, and future and was done in short forms and long and on and on. Fantasy always lagged behind as a commercial genre. It was really Wollheim pirating Tolkien for Ace that finally caused Tolkien or his "people" to get off their high-horse and allow Ballantine to produce "authorized" paperbacks instead of high-priced hardcovers. And, lo!, they became hugely successful and led to the Ballantine "Adult Fantasy" series (strange name there, I tell ya) and to the eventual fantasy behemoth we now witness. Tolkien was known and esteemed and all this before then (as were stray fantasies), but it was really the mass-market paperbacks that kicked this all off. So it's just a different history. Tolkien created this gigantic medievaloid secondary world playground of elves and orcs and that was that. Everybody copied it. SF began in magazines with multiple authors; commercial fantasy began as a book by a guy.
Obviously, Doc Smith's space opera and Heinlein's and Asimov's future histories and van Vogt's craziness and
Dune and
Neuromancer and suchlike have had their influences but, no, SF is too big and various to have a "trendsetter" like Tolkien since Tolkien wasn't so much a trendsetter as a genre-creator. Now, fantasy is also too big and various in its own way and fans should probably be very displeased at the magnitude of LOTR in the fantasy landscape (and some are) but I think it still pretty much defines fantasy in the same Star Wars does SF, except more so. The public mind thinks "LOTR" (or Harry Potter) and "Star Wars" but a lot more fantasy seems to actually be like LOTR than SF is like Star Wars. But I digress.
Long story short: I agree with others' answer to the topic question: no.