That's an even more interesting topic - imagine humans specifically adapted for zero-gravity for long flights? Does this mean humans adapted for different environments would be either desirable or acceptable? If so, doesn't that mean homo sapiens as a species could diverge into many species? If so, how would they regard us? Originals to be respected, or degenerates?
Lois McMaster Bujold covers this in various ways. Jackson's Whole is the extreme end, with exploitation. There are also the Quaddies - who have four arms - two where the legs were. They were created for work in null g and have formed their own society. The Cetagandans are busy running a massive social and genetic experiment on themselves - which is in its way subtle - so no grotesques, but they are working for optimum human beings in several ways. Some of the non-Cetagandan characters comment on this and wonder what Cetagandans will be at the end of it.
In terms of sex - later bits in the the thread - LMB also covers social aspects of this at times, commenting that a lot of the restrictions were designed to either control birth rate, or ensure parentage in a world before contraception and DNA testing. If you can't control the ovaries, you have to control the whole woman.
I would also say that in terms of the impact on the individual, training people to be part of the society they are born into - as in socially acceptable behaviour - involves stick as well as carrot. You make someone feel rotten about doing something and they either stop doing it, or do it secretly. This causes all sorts of inhibitions and knock-ons later.
John Barnes has an interesting series which starts with A Million Open Doors. In the backstory, earth went through a period of colonising planets, including marginal ones that needed terraforming, and there was a massive diaspora of various groups, with some groups getting a planet of their own to form a totally new society, others having to share. It was a mix of ethnic groups - such as Fijians, Tamil - and cultural groups. A number of groups were created from scratch - as in artificially created societies, some derived from a time in the human past or from a philosophy. There was then a massive selection process. Not all groups got to have a planet, and then the loosers had to reintegrate with mainstream society - the idea being that a homogenous earth would be a peaceful earth. The story kicks off on a planet based on a recreated ideal of a troubadour society, with duels, beautiful maidens and the like.