I completely agree with you on that. I'm left handed, so I always change the keys to something that suits me better. I still use WSAD, but I can't reach Alt, for instance. Though how right handed people reach Ctrl + a number effectivly is beyond me.
Another thing I hate is that every FPS insist you are right-handed. I remember an Unreal Tourmanet-game let you hold the gun on the left side of the screen, but more or less all FPSs the last ten, fifteen years have it on the right side only. It might not seem like much, but having it on the left side made a lot of difference to me. When I have it on the left side, it felt like an extension to my hand and made aiming a lot easier. Having it on the right side means I have to rely on the crosshair and hope I aim in the general area I want to hit. Thank god for rocket lauchers.
I can't wait for Skyrim, but I'm still skeptic. it's not just that I hated Oblivion, but it's mostly that so many games have gone to consoles the last few years. If I'm not mistaken, PC game sales have increased lately, but they are still love. What this means is games sell more on consoles, so they stay there. It's not bad most of the time, but console-games are so simple to control. I remember playing X-Wing and TIE Fighter, and we had to use a flightstick and a large part of the keyboard just to control our ships. I loved it. Same with Comanche: Maximum Overkill. The weapons alone were on the Z to B or so keys, and then there was the speed, altitude, radar, targeting, map etc. I loved it.
(sidenote: My father hated it and didn't want me to play it since "Maximum overkill" sounded so violent. I had a hard time explaining to him that it was a helicopter sim.)